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We have developed over 100 patient derived cultures from breast tumors of stages 0-IV (N=60) (JL-BTLs), non-tumor adjacent tissues (N= 54) (JL-NTALs) and breast reduction mammoplasties (N= 40) (JL-BRLs) using a novel tissue engineering system.
These patient derived cultures are from women and men of different ancestries that include Afro-Caribbean, African American, Hispanic and Non Hispanic White. Our breast tissue engineering system and some of these cultures have been published (see below).
Published Cultures
- Latimer, J.J., Nazir, T., Flowers, L.C., Forlenza, M.J., Beaudry-Rodgers, Kelly, C.M., Conte, J.A.,
Shestak, K., Kanbour-Shakir, A., and Grant, S.G. (2003). Unique tissue-specific level
of DNA nucleotide excision repair in primary human mammary epithelial cultures. Experimental
Cell Res 291: 111-121. doi: 10.1016/s0014-4827(03)00368-9 (Multiple JL-BRLs)
- Latimer, J.J., Rubinstein, W.S., Johnson, J.M., Kanbour-Shakir, A., Vogel, V.G., and Grant, S.G.
(2005). Haploinsufficiency for BRCA1 is associated with normal levels of DNA nucleotide
excision repair in breast tissue and blood lymphocytes. BMC Medical Genetics 6: 26
(published online 06-14-05). doi: 10.1186/1471-2350-6-26 (Multiple JL-BRLs)
- Latimer, J.J., Johnson, J.M., Miles, T.D., Dimsdale, J.M., Edwards, R.P., Kelley, J.L., and Grant,
S.G. (2008). Cell-type-specific level of DNA nucleotide excision repair in primary
human mammary and ovarian epithelial cell cultures. Cell and Tissue Research 333:
461–467 (published online 6-25-08). doi: 10.1007/s00441-008-0645-1 (Multiple JL-BRLs)
- Sajithlal, G.S., Rothermund, K., Zhang, F., Dabbs, D.J., Latimer, J.J., Grant, S.G., and Prochownik, E.V. (2010). Permanently blocked stem cells derived
from breast cancer cell lines. Stem Cells 28: 1008–1018 (published online 4-7-10).
doi: 10.1002/stem.424 (JL-BTL-12)
- Latimer, J.J., Johnson, J.M., Kelly, C.M., Miles, T.D., Beaudry-Rodgers, K.A., Lalanne, N.A.,
Vogel, V.G., Kanbour-Shakir, A., Kelley, J.L., Johnson, R.J., and Grant, S.G. (2010).
Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer.
Proceedings of the National Academy of Sciences (U.S.A.) 50: 21725–21730 (published
online 11-30-10). doi: 10.1073/pnas.0914772107 (JL-BTL-4, JL-BTL-8, JL-BTL-33)
- Visus, C., Ito, D., Dhir, R., Szczepanski M.J., Chang, Y. J., Latimer, J.J., Grant, S.G., and DeLeo, A.B. (2011). Identification of hydroxysteroid (17) dehydrogenase
type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomas.
Cancer Immunology Immunotherapy 60: 919–929 (published online 3-16-11). doi: 10.1007/s00262-011-1001-y
(JL-BRL-6)
- Wend, P., Runke, S., Wend, K., Anchondo, B., Yesayan, M., Jardan, M., Hardie, N.,
Loddenkemper, C., Ulasov, I., Lesniak, M.S., Wolsky, R., Bentolila, L.A., Grant, S.G.,
Elashoof, D., Lehr, S., Latimer, J.J., Bose, S., Sattar, H., Krum, S.A., and Miranda-Carboni, G.A. (2013). WNT10B/β‐catenin
signaling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.
EMBO Molecular Medicine 5: 1–16 (published online 1-11-13). doi: 10.1002/emmm.201201320
(JL-BTL-10)
- Dodda, B., Corry, D., Bondi, C.D., Hasan, M., Clafshenkel, W.P., Gallagher, K.M.,
Kotlarczyk, M.P., Sethi,S., Buszko, E., Latimer, J.J., Cline, J.M, Witt-Enderby, P.A. and Davis, V.L. (2019). Co-administering Melatonin
with an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer
Development in a Mouse Model of HER2-positive Breast Cancer, Frontiers in Oncology
9: 525 doi: 10.3389/fonc.2019.00525 (JL-BTL-12)
- Almutairy, A.F., Alhamed, A.S., Grant, S.G., Falso, M.J., Day, B.W., Simmons, C.R, Latimer, J.J. (2024) Cancer-Specific Alterations in Nuclear Matrix Proteins Determined by Multi-Omics Analyses of Ductal Carcinoma In Situ, Frontiers in Oncology, doi: 10.3389/fonc.2024.1406946 (JL-DCIS-3, JL-Contra-3, JL-BRL-6, plus patient derived cultures from stages I, II, III and IV)